| Abstract |
Background: Côte d’Ivoire has the highest prevalence rate of HIV infection in West Africa. HIV infection causes metabolic disorders especially in micronutrients needed by the body for normal body growth and development. The present study was undertaken to investigate the level of serum copper, zinc and iron as well as their relationship with the degree of immunosuppression. Methods: The study population consisted of 254 adults with 127 people living with HIV (PLHIV) and 127 HIV-negative people. The Flame Atomic Absorption spectrophotometry method was used for determination of serum trace elements. CD4+ T-lymphocytes count was performed using flow cytometry (FacsCalibur). Results: Compared to HIV-control population, the mean concentrations of copper, zinc and iron in PLHIV were 2600±160 ng/mL (p=0.087), 2200±76 ng/mL (p<0.0001) and 3417±290 ng/mL (p<0.0001) respectively. This study showed a significant increase in mean values of zinc (p<0.0001) and a significant decrease mean values of iron (p<0.0001) in PLHIV. Furthermore, CD4+ T-lymphocytes cell count had a negative correlation with serum copper level (r= -0.18, p=0.041) and no correlation with levels of zinc (r= - 0.06, p=0.526) and iron (p=0.710). Conclusions: This study showed an increase in serum zinc level and a remarkable reduction in serum iron in PLHIV compared to controls population.
KEYWORDS: Abidjan, Antiretroviral therapy, HIV-patients, Trace elements concentrations.
|
